Domain

GTP1/OBG domain (IPR006169)

Short name: GTP1_OBG_dom

Domain relationships

None.

Description

The N-terminal domain of GTPase Obg has the OBG fold, which is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich these regions form six left-handed collagen-like helices packed and H-bonded together.

Several proteins have recently been shown to contain the 5 structural motifs characteristic of GTP-binding proteins [PMID: 1449490]. These include murine DRG protein; GTP1 protein from Schizosaccharomyces pombe; OBG protein from Bacillus subtilis; and several others. Although the proteins contain GTP-binding motifs and are similar to each other, they do not share sequence similarity to other GTP-binding proteins, and have thus been classed as a novel group, the GTP1/OBG family. As yet, the functions of these proteins is uncertain, but they have been shown to be important in development and normal cell metabolism [PMID: 8462872, PMID: 2537815].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam