Glycerol-3-phosphate dehydrogenase, NAD-dependent (IPR006168)

Short name: G3P_DH_NAD-dep

Overlapping homologous superfamilies

Family relationships


NAD-dependent glycerol-3-phosphate dehydrogenase (EC: (GPD) catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate. It is a cytoplasmic protein, active as a homodimer [PMID: 2500660], each monomer containing an N-terminal NAD binding site [PMID: 6773774]. In insects, it acts in conjunction with a mitochondrial alpha-glycerophosphate oxidase in the alpha-glycerophosphate cycle, which is essential for the production of energy used in insect flight [PMID: 2500660].

GO terms

Biological Process

GO:0006072 glycerol-3-phosphate metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity

Cellular Component

GO:0009331 glycerol-3-phosphate dehydrogenase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns