DNA repair protein XPF (IPR006167)

Short name: XPF

Overlapping homologous superfamilies


Family relationships



This entry includes XPF from animals, Rad1 from budding yeasts and Rad16 from fission yeasts. Human XPF is a catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. It is involved in homologous recombination that assists in removing interstrand cross-link [PMID: 19596235]. Budding yeast Rad1 and Rad10 form an endonuclease that specifically degrades single-stranded DNA [PMID: 8479526].

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0004520 endodeoxyribonuclease activity
GO:0003697 single-stranded DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.