Domain

Ku70/Ku80 beta-barrel domain (IPR006164)

Short name: Ku70/Ku80_beta-barrel_dom

Domain relationships

None.

Description

The Ku heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the central DNA-binding beta-barrel domain. This domain is found in both the Ku70 and Ku80 proteins that form a DNA binding heterodimer [PMID: 11493912].

GO terms

Biological Process

GO:0006303 double-strand break repair via nonhomologous end joining

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam