Domain

Dihydroneopterin aldolase/epimerase domain (IPR006157)

Short name: FolB_dom

Domain relationships

None.

Description

Dihydroneopterin aldolase catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate. In the opportunistic pathogen Pneumocystis carinii, dihydroneopterin aldolase function is expressed as the N-terminal portion of the multifunctional folic acid synthesis protein (Fas). This region encompasses two domains, FasA and FasB, which are 27% amino acid identical. FasA and FasB also share significant amino acid sequence similarity with bacterial dihydroneopterin aldolases.

This region consists of two tandem sequences each homologous to folB and which form tetramers [PMID: 9709001].

GO terms

Biological Process

GO:0006760 folic acid-containing compound metabolic process

Molecular Function

GO:0004150 dihydroneopterin aldolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
Pfam
SMART