Heavy metal-associated domain, copper ion-binding (IPR006122)

Short name: HMA_Cu_ion-bd

Overlapping homologous superfamilies

Domain relationships


Proteins that transport heavy metals in micro-organisms and eukaryotes share similarities in their sequences and structures.

These proteins provide an important focus for research, some being involved in bacterial resistance to toxic metals, such as lead and cadmium, while others are involved in inherited human syndromes, such as Wilson's and Menke's diseases [PMID: 8091505].

A conserved 30-residue domain has been found in a number of these heavy metal transport or detoxification proteins [PMID: 8091505]. The domain, which has been termed Heavy-Metal-Associated (HMA), contains two conserved cysteines that are probably involved in metal binding. This sub-domain is found in copper-binding proteins.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005507 copper ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.