Conserved Site

Acyl-CoA dehydrogenase, conserved site (IPR006089)

Short name: Acyl-CoA_DH_CS


Mammalian Co-A dehydrogenases (EC: are enzymes that catalyse the first step in each cycle of beta-oxidation in mitochondion. Acyl-CoA dehydrogenases [PMID: 3326738, PMID: 2777793, PMID: 8034667] catalyze the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD. Reoxidation of the flavin involves transfer of electrons to ETF (electron transfering flavoprotein) [PMID: 8356049]. These enzymes are homodimers containing one molecule of FAD.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0003995 acyl-CoA dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns