Phosphoribulokinase (IPR006082)

Short name: PRK

Overlapping homologous superfamilies

Family relationships



Phosphoribulokinase (PRK) EC: catalyses the ATP-dependent phosphorylation of ribulose-5-phosphate to ribulose-1,5-phosphate, a key step in the pentose phosphate pathway where carbon dioxide is assimilated by autotrophic organisms [PMID: 2175647]. In general, plant enzymes are light-activated by the thioredoxin/ferredoxin system, while those from photosynthetic bacteria are regulated by a system that has an absolute requirement for NADH. Thioredoxin/ferredoxin regulation is mediated by the reversible oxidation/reduction of sulphydryl and disulphide groups. In the spinach enzyme (P09559) the participating residues are Cys-16 and Cys-55. Sequence analysis shows the first of these cysteines to be present in the ATP-binding site [PMID: 2826432]; neither is found in the bacterial sequences.

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0005524 ATP binding
GO:0008974 phosphoribulokinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns