Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA (IPR006063)

Short name: HisA

Overlapping homologous superfamilies

Family relationships


1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:, also known as Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase or HisA, catalyses the fourth step in histidine biosynthesis. HisA from Lactococcus lactis was found to be inactive [PMID: 7687248]. The putative HisA from Thermotoga maritima, is a conspicuous outlier to the set of all other HisA, including experimental HisA from the bacterium Escherichia coli and the Archaeaon Methanococcus voltae. Neighbor joining shows HisA from Thermotoga maritima to be within the HisA family (with HisF as an outgroup) but with a long branch.

GO terms

Biological Process

GO:0000105 histidine biosynthetic process

Molecular Function

GO:0003949 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.