Phosphotyrosine interaction domain, Shc-like (IPR006019)

Short name: PID_Shc-like

Overlapping homologous superfamilies

Domain relationships

  • PTB/PI domain (IPR006020)
    • Phosphotyrosine interaction domain, Shc-like (IPR006019)


Shc proteins contain an SH2 domain and a phosphotyrosine interaction (PI) domain. These domains facilitate interaction with various activated tyrosine-phosphorylated receptors, including those of growth factors, insulin, cytokines and lymphocytes. The PI domain comprises 165 residues, 4 of which (Arg67, Arg175, Ser151 and Lys169 [PMID: 8646778]) are responsible for binding phosphotyrosine on a `IIENPQYFSDA'(NPxPY) peptide [PMID: 7541035].

The PI domain has a similar structure to the insulin receptor substrate-1 PTB domain, a 7-stranded beta-sandwich, capped by a C-terminal helix. However, the PI domain contains an additional short N-terminal helix and a large insertion between strands 1 and 2, which forms a helix and 2 long connecting loops. The substrate peptide fits into a surface cleft formed from the C-terminal helix and strand 5 [PMID: 8599766].

GO terms

Biological Process

GO:0035556 intracellular signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.