Caldesmon/lymphocyte specific protein (IPR006018)

Short name: Caldesmon_LSP

Overlapping homologous superfamilies


Family relationships


This group of proteins includes two protein families: caldesmon and lymphocyte specific protein.

Caldesmon (CDM) is an actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and non-muscle cells, possibly acting as a bridge between myosin and actin filaments [PMID: 1555769]. CDM is believed to be an elongated molecule, with an N-terminal myosin/calmodulin- binding domain and a C-terminal tropomyosin/actin/calmodulin-binding domain, separated by a 40nm-long central helix [PMID: 1555769].

A high-molecular-weight form of CDM is predominantly expressed in smooth muscles, while a low-molecular-weight form is widely distributed in non- muscle tissues and cells (the protein is not expressed in skeletal muscle or heart).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.