UspA (IPR006016)

Short name: UspA

Overlapping homologous superfamilies

Domain relationships



This entry represents a domain found in the universal stress protein UspA P28242 [PMID: 8152377], which is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA [PMID: 11738040] reveals an alpha/beta fold similar to that of the Methanocaldococcus jannaschii (Methanococcus jannaschii) MJ0577 protein, which binds ATP [PMID: 9860944], though UspA lacks ATP-binding activity.

Proteins containing this domain include the TeaD protein from Halomonas elongata. TeaD regulates the ectoine uptake by the transporter TeaABC. TeaD shows an ATP-dependent oligomerisation [PMID: 20113006].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.