Family

Universal stress protein A (IPR006015)

Short name: Universal_stress_UspA

Family relationships

None.

Description

Transcriptional induction of the uspA gene of Escherichia coli occurs when conditions cause growth arrest; cells deficient in UspA survive poorly in stationary phase [PMID: 9405142]. The product of uspA has been shown to be a cytoplasmic serine and threonine phosphoprotein. Members of the Usp family are predicted to be related to the MADS-box proteins and bind to DNA [PMID: 9405142]. Some members of the family contain 2 copies of the domain.

The structure of a UspA homologue from Methanocaldococcus jannaschii (Methanococcus jannaschii) from has been determined to 1.8 angstroms resolution by using its selenomethionyl derivative and multiwavelength anomalous diffraction. The protein homodimerises in the crystal; each monomer adopts an open-twisted 5-stranded parallel beta-sheet with 2 helices on each side of the sheet [PMID: 9860944]. Although the structure co-crystallised with ATP, the function of the protein is unknown.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
PRINTS