Guanosine monophosphate reductase, type2 (IPR005994)

Short name: GuaC_type_2

Overlapping homologous superfamilies

Family relationships



Guanosine monophosphate reductase (EC: catalyzes the irreversible and NADPH-dependent reductive deamination of GMP into IMP. NADPH + guanosine 5-phosphate = NADP+ + inosine 5-phosphate + NH3

It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides. A deep split separates two families of GMP reductase. This family is found in a variety of bacterial lineages. The other type (IPR005993) is found in eukaryotic and some proteobacterial lineages.

GO terms

Biological Process

GO:0006163 purine nucleotide metabolic process

Molecular Function

GO:0003920 GMP reductase activity

Cellular Component

GO:1902560 GMP reductase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.