Family

GMP reductase (IPR005993)

Short name: GMPR

Family relationships

None.

Description

GMP (guanosine monophosphate) reductase catalyses the irreversible and NADPH-dependent reductive deamination of GMP into IMP. NADPH + guanosine 5-phosphate = NADP+ + inosine 5-phosphate + NH3

It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides. A deep split separates two families of GMP reductase. This family includes both eukaryotic and some proteobacterial sequences.

GO terms

Biological Process

GO:0009117 nucleotide metabolic process

Molecular Function

GO:0003920 GMP reductase activity

Cellular Component

GO:1902560 GMP reductase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
PIRSF
HAMAP