Tyrosine 3-monooxygenase (IPR005962)

Short name: Tyr_3_mOase

Overlapping homologous superfamilies

Family relationships


Tyrosine 3-monooxygenase (EC:, is a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tryptophan 5-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in some Gram-negative bacteria. It catalyses the first step in catecholamine biosynthesis. L-tyrosine + tetrahydropteridine + O2 = 3,4-dihydroxy-L-phenylalanine + dihydropteridine + H2O.

GO terms

Biological Process

GO:0042423 catecholamine biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004511 tyrosine 3-monooxygenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.