Phenylalanine-4-hydroxylase, monomeric form (IPR005960)

Short name: Phe-4-hydroxylase_mono

Overlapping homologous superfamilies

Family relationships


This entry represents the small, monomeric form of phenylalanine-4-hydroxylase (PAH; EC:, as found in a certain Gram-negative bacteria. The enzyme is biopterin and metal dependent, and acts to irreversibly convert phenylalanine to tyrosine, the rate-limiting step in phenylalanine catabolism in some systems:

L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + dihydrobiopterin + H2O

The structure of PAH from Colwellia psychrerythraea (strain 34H / ATCC BAA-681), which binds tetrahydrobiopterin (BH4) as cofactor, is a cold-active form of the enzyme that has increased stability and flexibility around the active site [PMID: 17537732].

GO terms

Biological Process

GO:0006559 L-phenylalanine catabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004505 phenylalanine 4-monooxygenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.