Formate acetyltransferase (IPR005949)

Short name: Form_AcTrfase

Family relationships



Pyruvate formate-lyase EC: (also known as formate C-acetyltransferase) is an enzyme which converts acetyl-CoA and formate to CoA and pyruvate. Acetyl-CoA + formate = CoA + pyruvate In Escherichia coli, it uses a radical mechanism to reversibly cleave the C1-C2 bond of pyruvate using the Gly 734 radical and two cysteine residues (Cys 418, Cys 419) [PMID: 10504733].

This family comprises formate acetyltransferase 1. More distantly related putative formate acetyltransferases have also been identified, including formate acetyltransferase 2 from E. coli, which is excluded from this model.

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0008861 formate C-acetyltransferase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.