1-pyrroline-5-carboxylate dehydrogenase (IPR005932)

Short name: RocA

Overlapping homologous superfamilies

Family relationships



This entry represents a group of putative 1-pyrroline-5-carboxylate dehydrogenases (RocA) from Bacillales [PMID: 12634342] and other bacteria [PMID: 16934832]. They are related to delta-1-pyrroline-5-carboxylate dehydrogenase (EC=; IPR005931) [PMID: 12604184], which is an aldehyde dehydrogenase that catalyses the oxidation of glutamate semialdehyde to glutamate [PMID: 22516612], utilizing NAD+ as the electron acceptor. In some bacteria, the two enzymes are fused into the bifunctional flavoenzyme, proline utilization A (PutA) [PMID: 15966737, PMID: 18931443, PMID: 18324349]. In this entry, monofunctional enzyme sequences such as seen in the Bacillus subtilis RocA P5CDH are also present [PMID: 12634342]. These enzymes play important roles in cellular redox control, superoxide generation, and apoptosis.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.