Delta-1-pyrroline-5-carboxylate dehydrogenase (IPR005931)

Short name: P5CDH/ALDH4A1

Overlapping homologous superfamilies

Family relationships



This entry represents one of two related branches of delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDH, EC:; also known as ALDH4A1 in humans). It is responsible for the NAD+-dependent, irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate [PMID: 22516612, PMID: 18369526]. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. P5CDH is a mitochondrial homodimer and a member of the aldehyde dehydrogenase (ALDH) protein superfamily. Also included in this entry is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences [PMID: 18611112, PMID: 12604184].

GO terms

Biological Process

GO:0010133 proline catabolic process to glutamate

Molecular Function

GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.