Family

Imidazolonepropionase (IPR005920)

Short name: HutI

Overlapping homologous superfamilies

Family relationships

None.

Description

Imidazolonepropionase catalyzes the third step in histidine degradation. It hydrolyses the carbon-nitrogen bonds in 4-imidazolone-5-propionic acid to yield N-formimino-l-glutamic acid [PMID: 16990261]. The enzyme contains two domains, a TIM (triose-phosphate isomerase) barrel domain with two insertions and a small beta-sandwich domain. It has been conserved from bacteria to eukaryotes [PMID: 16198643]. In bacteria, the enzyme is part of histidine utilization (hut) operon [PMID: 2842309].

GO terms

Biological Process

GO:0019556 histidine catabolic process to glutamate and formamide

Molecular Function

GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
TIGRFAMs
PANTHER
HAMAP