Acetoacetyl-CoA synthase (IPR005914)

Short name: Acac_CoA_synth

Overlapping homologous superfamilies


Family relationships



Isoprenoids are a large class of compounds, with more than 20,000 structures currently known, which are found in all living organisms. Some play essential physiological roles, such as sterols that stabilise cell membranes or carotenoids involved in photosynthesis, while the function of many others is not well understood. In all eukaryotes and some prokaryotes, isoprenoids are synthesised by the mevalonate pathway, while most prokaryotes use a mevalonate-independent pathway [PMID: 15604784, PMID: 8240251].

This entry represents acetoacetyl-CoA synthase (EC:, catalysing the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA

A Sinorhizobium protein in this entry is also required for growth on polyhydroxybutyrate, a commonly used carbon storage molecule in bacteria [PMID: 10735852]. This entry also includes malonamoyl-CoA synthetase which in Penicillium is involved in the biosynthesis of the tetracycline-like viridicatumtoxin [PMID: 20534346].

GO terms

Biological Process

GO:0006629 lipid metabolic process

Molecular Function

GO:0030729 acetoacetate-CoA ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.