dTDP-4-dehydrorhamnose reductase family (IPR005913)

Short name: dTDP_dehydrorham_reduct

Overlapping homologous superfamilies

Family relationships



dTDP-4-dehydrorhamnose reductase (EC: catalyses the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose, which is the final step in the conversion of dTDP-D-glucose to dTDP-L-rhamnose [PMID: 21640586]. dTDP-rhamnose is essential for growth of mycobacteria [PMID: 12029057]. dTDP-L-rhamnose is the precursor of L-Rhamnose (L-Rha), a component of the lipopolysaccharide (LPS) core and several O antigen polysaccharides of Pseudomonas [PMID: 11065359].

Methionine adenosyltransferase 2 subunit beta (MAT2B) also belongs to this family. It is the regulatory subunit of MAT2A, an enzyme that catalyses the formation of S-adenosylmethionine (AdoMet) from methionine and ATP [PMID: 10644686].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.