dTDP-glucose 4,6-dehydratase (IPR005888)

Short name: dTDP_Gluc_deHydtase

Overlapping homologous superfamilies

Family relationships


The conversion of dTDP-glucose into dTDP-4-keto-6-deoxyglucose by Escherichia coli dTDP-glucose 4,6-dehydratase) takes place in the active site in three steps: dehydrogenation to dTDP-4-ketoglucose, dehydration to dTDP-4-ketoglucose-5,6-ene, and rereduction of C6 to the methyl group. The 4,6-dehydratase makes use of tightly bound NAD+ as the coenzyme for transiently oxidizing the substrate, activating it for the dehydration step [PMID: 11851427]. This and other 4,6-dehydratases catalyze the first committed step in all 6-deoxysugar biosynthetic pathways described to date. Numerous 6-deoxysugars are used in bacterial lipopolysaccharide production as well as in the biosynthesis of a diverse array of secondary metabolites.

GO terms

Biological Process

GO:0009225 nucleotide-sugar metabolic process

Molecular Function

GO:0008460 dTDP-glucose 4,6-dehydratase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.