Phosphoglucomutase, alpha-D-glucose specific (IPR005852)

Short name: PGlcMutase_a-D-Glc-sp

Overlapping homologous superfamilies

Family relationships



Phosphoglucomutase, alpha-D-glucose phosphate-specific (EC: links the anaerobic or aerobic glycolysis of glucose-6-phosphate and glucose-1-phosphate produced by various glycan phosphorylases by catalysing the transfer of a phosphate group between C-1 and C-6 of glucose [PMID: 15299905].

Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.

The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model [PMID: 10506283, PMID: 9549096, PMID: 15238632].

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0004614 phosphoglucomutase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.