Domain

Galactose-1-phosphate uridyl transferase, N-terminal (IPR005849)

Short name: GalP_Utransf_N

Domain relationships

None.

Description

Galactose-1-phosphate uridyl transferase catalyses the conversion of UDP-glucose and alpha-D-galactose 1-phosphate to alpha-D-glucose 1-phosphate and UDP-galactose during galactose metabolism. The enzyme is present in prokaryotes and eukaryotes. Defects in GalT in humans is the cause of galactosemia, an inherited disorder of galactose metabolism that leads to jaundice, cataracts and mental retardation.

This domain describes the C-terminal of Galactose-1-phosphate uridyl transferase. SCOP reports fold duplication of the C-terminal with the N-terminal domain. Both are involved in Zn and Fe binding

GO terms

Biological Process

GO:0006012 galactose metabolic process

Molecular Function

GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam