Methylthiotransferase (IPR005839)

Short name: Methylthiotransferase

Family relationships


This family contains four subfamilies, and includes the tRNA-i(6)A37 modification enzyme, MiaB (TIGR01574). The other three subfamilies are modelled by TIGR01125, TIGR01579 and TIGR01578. Together, the four subfamilies hit every sequence hit by the family model without any overlap between them.

MiaB acts on a particular isoprenylated Adenine base of certain tRNAs causing thiolation at an aromatic carbon, and probably also transferring a methyl group from SAM to the thiol. The particular substrate of the three other subfamilies is unknown but may be very closely related.

GO terms

Biological Process

GO:0043412 macromolecule modification

Molecular Function

GO:0051539 4 iron, 4 sulfur cluster binding
GO:0016740 transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.