Conserved Site

Aerolysin/haemolysin toxin, conserved site (IPR005831)

Short name: Aerolysin/haemolysin_CS


Aerolysin is a cytolytic toxin exported by the Gram-negative Aeromonas bacteria [PMID: 8845373]. The mature toxin binds to eukaryotic cells and aggregates to form holes (approximately 3 nm in diameter) leading to the destruction of the membrane permeability barrier and osmotic lysis. Staphylococcus aureus also exports a cytotoxin, alpha-toxin, whose biological activity is similar to that of aerolysin. The sequences of both toxins are not similar except for a stretch of ten residues rather well conserved.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns