Family

Aerolysin/haemolysin/leukocidin toxin (IPR005830)

Short name: Aerolysn_hemolysn_leukocdn_tox

Family relationships

Description

This family represents the pore forming lobe of aerolysin, and the related toxins haemolysin and the leukocidin S subunit.

Aerolysin [PMID: 3584074] is a cytolytic toxin exported by Aeromonas hydrophila, a Gram-negative bacterium associated with diarrhoeal diseases and deep wound infections [PMID: 7510043]. The mature toxin binds to eukaryotic cells and aggregates to form holes (approximately 3 nm in diameter) leading to the destruction of the membrane permeability barrier and osmotic lysis. The structure of proaerolysin has been determined to 2.8A resolution and shows the protoxin to adopt a novel fold [PMID: 7510043]. Images of an aerolysin oligomer derived from electron microscopy have helped to construct a model of the protein and to outline a mechanism by which it might insert into lipid bilayers to form ion channels [PMID: 7510043].

GO terms

Biological Process

GO:0009405 pathogenesis

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam