Histone H5 (IPR005819)

Short name: Histone_H5

Overlapping homologous superfamilies


Family relationships



Histone H5 is a nuclear protein involved in the condensation of nucleosome chains into higher order structures. In this respect, it performs the same function as histone H1, and replaces H1 in certain cells. The structure of GH5, the globular domain (residues 22-100) of the linker histone H5, has been solved. The fold is similar to the DNA-binding domain of the catabolite gene activator protein, CAP, thus providing a possible model for the binding of GH5 to DNA. The structure comprises 3 alpha-helices and 2 short beta-strands.

GO terms

Biological Process

GO:0006334 nucleosome assembly

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0000786 nucleosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.