Family

Aminotransferase class-III (IPR005814)

Short name: Aminotrans_3

Family relationships

Description

Aminotransferases share certain mechanistic features with other pyridoxalphosphate-dependent enzymes, such as the covalent binding of the pyridoxalphosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped [PMID: 1618757] into subfamilies. One of these, called class-III, includes acetylornithine aminotransferase (EC:2.6.1.11), which catalyzes the transfer of an amino group from acetylornithine to alpha-ketoglutarate, yielding N-acetyl-glutamic-5-semi-aldehyde and glutamic acid [PMID: 2199330]; ornithine aminotransferase (EC:2.6.1.13), which catalyzes the transfer of an amino group from ornithine to alpha-ketoglutarate, yielding glutamic-5-semi-aldehyde and glutamic acid [PMID: 3754226]; omega-amino acid--pyruvate aminotransferase (EC:2.6.1.18), which catalyzes transamination between a variety of omega-amino acids, mono- and diamines, and pyruvate [PMID: 2500426]; 4-aminobutyrate aminotransferase (EC:2.6.1.19) (GABA transaminase), which catalyzes the transfer of an amino group from GABA to alpha-ketoglutarate, yielding succinate semialdehyde and glutamic acid [PMID: 10989446]; DAPA aminotransferase (EC:2.6.1.62), a bacterial enzyme (bioA), which catalyzes an intermediate step in the biosynthesis of biotin, the transamination of 7-keto-8-aminopelargonic acid to form 7,8-diaminopelargonic acid [PMID: 1092681]; 2,2-dialkylglycine decarboxylase (EC:4.1.1.64), a Burkholderia cepacia (Pseudomonas cepacia) enzyme (dgdA) that catalyzes the decarboxylating amino transfer of 2,2-dialkylglycine and pyruvate to dialkyl ketone, alanine and carbon dioxide [PMID: 8342040]; glutamate-1-semialdehyde aminotransferase (EC:5.4.3.8) (GSA) [PMID: 2349227]; Bacillus subtilis aminotransferases yhxA and yodT; Haemophilus influenzae diaminobutyrate--2-oxoglutarate aminotransferase (HI0949) [PMID: 9514614]; and Caenorhabditis elegans alanine--glyoxylate aminotransferase 2-like (T01B11.2).

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0030170 pyridoxal phosphate binding
GO:0008483 transaminase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
PROSITE patterns
PIRSF
Pfam