Domain

Formyl transferase, C-terminal (IPR005793)

Short name: Formyl_trans_C

Domain relationships

Description

Methionyl-tRNA formyltransferase (EC:2.1.2.9) transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and by impairing its binding to EFTU-GTP. This family also includes formyltetrahydrofolate dehydrogenases, which produce formate from formyl-tetrahydrofolate. These enzymes contain an N-terminal domain in common with other formyl transferase enzymes (IPR002376). The C-terminal domain has an open beta-barrel fold [PMID: 8887566].

GO terms

Biological Process

GO:0009058 biosynthetic process

Molecular Function

GO:0016742 hydroxymethyl-, formyl- and related transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
Pfam