Family

Tetrahydromethanopterin S-methyltransferase, subunit D (IPR005779)

Short name: MeTrfase_D

Family relationships

None.

Description

This model describes N5-methyltetrahydromethanopterin: coenzyme M methyltransferase subunit D in methanogenic archaea. This methyltranferase is a membrane-associated enzyme complex that uses methyl-transfer reaction to drive sodium-ion pump. 5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulphonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulphonate. Archaea have evolved energy-yielding pathways marked by one-carbon biochemistry featuring novel cofactors and enzymes. This transferase (encoded by subunit A) is involved in the transfer of 'methyl' group from N5-methyltetrahydromethanopterin to coenzyme M. In an accompanying reaction, methane is produced by two-electron reduction of methyl-coenzyme M by another enzyme, methyl-coenzyme M reductase.

GO terms

Biological Process

GO:0006814 sodium ion transport

Molecular Function

GO:0030269 tetrahydromethanopterin S-methyltransferase activity

Cellular Component

GO:0005737 cytoplasm
GO:0012506 vesicle membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
Pfam
HAMAP
ProDom
TIGRFAMs