Sortase family (IPR005754)

Short name: Sortase

Overlapping homologous superfamilies

Family relationships


This family includes Staphylococcus aureus sortase, a transpeptidase that attaches surface proteins by the Thr of an LPXTG motif to the cell wall. It also includes a protein required for correct assembly of an LPXTG-containing fimbrial protein, a set of homologous proteins from Streptococcus pneumoniae, in which LPXTG proteins are common. However, related proteins are found in Bacillus subtilis and Methanobacterium thermoautotrophicum, in which LPXTG-mediated cell wall attachment is not known [PMID: 10427003].

Sortase refers to a group of prokaryotic enzymes which catalyze the assembly of pilins into pili, and the anchoring of pili to the cell wall [PMID: 2544515]. They act as both proteases and transpeptidases [PMID: 2519520]. Sortase, a transpeptidase present in almost all Gram-positive bacteria, anchors a range of important surface proteins to the cell wall [PMID: 11401711, PMID: 14572546]. The sortases are thought to be good targets for new antibiotics as they are important proteins for pathogenic bacteria [PMID: 18321961].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.