Endonuclease MutS2 (IPR005747)

Short name: MutS2

Overlapping homologous superfamilies

Family relationships



The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair. Homologues of MutS have been found in many species including eukaryotes (MSH 1, 2, 3, 4, 5, and 6 proteins), archaea and bacteria, and together these proteins have been grouped into the MutS family. Although many of these proteins have similar activities to the E. coli MutS, there is significant diversity of function among the MutS family members. Inter-species homologues may have arisen through frequent ancient horizontal gene transfer of MutS (and MutL) from bacteria to archaea and eukaryotes via endosymbiotic ancestors of mitochondria and chloroplasts [PMID: 17965091].

This entry represents endonuclease MutS2. MutS2 is a paralogue of MutS and is not involved in DNA mismatch repair but in the suppression of homologous recombination [PMID: 15629722, PMID: 15866941, PMID: 18838375, PMID: 15113836]. It may therefore have a key role in the control of bacterial genetic diversity.

GO terms

Biological Process

GO:0045910 negative regulation of DNA recombination

Molecular Function

GO:0016887 ATPase activity
GO:0004519 endonuclease activity
GO:0030983 mismatched DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.