Mitochondrial import receptor subunit Tom40 (IPR005686)

Short name: Tom40

Family relationships


Tom40 is a mitochondrion outer membrane protein and a component of the TOM (translocator of the outer mitochondrial membrane) complex, which is essential for import of protein precursors into mitochondria [PMID: 10427088]. In Saccharomyces cerevisiae, TOM complex is composed of the subunits Tom70, Tom40, Tom22, Tom20, Tom7, Tom6, and Tom5 [PMID: 1327874, PMID: 9774667]. Tom40 is an integral membrane protein and the main structural component of the protein-conducting channel formed by the TOM complex [PMID: 14595396]. It is stabilised by other components, such as Tom5, Tom6, and Tom7 [PMID: 11866524].

GO terms

Biological Process

GO:0030150 protein import into mitochondrial matrix

Molecular Function

GO:0015266 protein channel activity

Cellular Component

GO:0005741 mitochondrial outer membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.