Ribosomal protein S12, bacterial-type (IPR005679)

Short name: Ribosomal_S12_bac

Overlapping homologous superfamilies

Family relationships


Ribosomal protein S12 is located at the interface of the large and small ribosomal subunits, where it plays an important role in both tRNA and ribosomal subunit interactions. S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation [PMID: 14536072]. Antibiotics such as streptomycin bind S12 and cause the ribosome to misread the genetic code [PMID: 15866943, PMID: 11863397, PMID: 11371156].

This family consists of ribosomal protein S12 from bacteria, mitochondria, and chloroplasts.

GO terms

Biological Process

GO:0006412 translation

Molecular Function

GO:0003735 structural constituent of ribosome

Cellular Component

GO:0015935 small ribosomal subunit

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.