Fumarate hydratase, class II (IPR005677)

Short name: Fum_hydII

Overlapping homologous superfamilies

Family relationships


Fumarate hydratase class II (also known as Fumarase C) catalyses the stereospecific interconversion of fumarate to L-malate as part of the metabolic citric acid or Kreb's cycle. The recent three-dimensional structure of fumarase C from Escherichia coli has identified a binding site for anions which is generated by side chains from three of the four subunits within the tetramer. These same side chains are found in the three most highly conserved regions within the class II fumarate hydratase family. Putative fumarases from several species (Mycobacterium tuberculosis, Streptomyces coelicolor, Pseudomonas aeruginosa) branch deeply, although within the same branch of a phylogenetic tree rooted by aspartate ammonia-lyase sequences.

GO terms

Biological Process

GO:0006106 fumarate metabolic process

Molecular Function

GO:0004333 fumarate hydratase activity

Cellular Component

GO:0045239 tricarboxylic acid cycle enzyme complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.