Phosphate transport system permease protein 1 (IPR005670)

Short name: Phosp_transpt1

Overlapping homologous superfamilies

Family relationships



This is a family of phosphate transport system permease proteins. They are membrane transport proteins that use the hydrolysis of ATP to function. They contain ABC (ATP-binding cassette-type) transporter domains.

Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein is a phosphate-binding protein located in the periplasmic space [PMID: 9671506]. PstA and PstC are hydrophobic and they form the transmembrane portion of the Pst system [PMID: 1447208]. PstB is the catalytic subunit, which couples the energy of ATP hydrolysis to the import of phosphate across cellular membranes through the Pst system, often referred as ABC-protein. PstB belongs to one of the largest superfamilies of proteins characterized by a highly conserved adenosine triphosphate (ATP) binding cassette (ABC), which is also a nucleotide binding domain (NBD) [PMID: 8682808].

GO terms

Biological Process

GO:0035435 phosphate ion transmembrane transport

Molecular Function

GO:0005315 inorganic phosphate transmembrane transporter activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
  • cd03260 (ABC_PstB_phosphate_transporter)