Thiosulphate/Sulfate-binding protein (IPR005669)

Short name: Thiosulph/SO4-bd

Overlapping homologous superfamilies


Family relationships



This entry represents thiosulfate/sulfate binding proteins. Sulfate binding protein (SBP) specifically binds sulfate [PMID: 3885043] and thiosulfate-binding protein (TSBP or CysP) specifically binds thiosulfate. They are involved in the ABC transport of sulfate and thiosulfate in eubacteria [PMID: 7608089].

This family are an example of type 2 periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap [PMID: 11741199].

GO terms

Biological Process

GO:0008272 sulfate transport

Molecular Function

GO:0015419 ATPase-coupled sulfate transmembrane transporter activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.