GTP-binding protein Era (IPR005662)

Short name: GTP-bd_Era

Overlapping homologous superfamilies

Family relationships



Era is an essential G-protein in Escherichia coli identified originally as a homologue protein to Ras (E. coli Ras-like protein). It binds to GTP/GDP and contains a low intrinsic GTPase activity. Its function remains elusive, although it may be associated with cell division, energy metabolism, and cell-cycle check point. The protein has recently been shown to specifically bind to 16S rRNA and the 30S ribosomal subunit [PMID: 10527840]. Involvement of Era in protein synthesis is suggested by the fact that Era depletion results in the translation defect both in vitro and in vivo. A Type 2 KH domain is found near the C terminus.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005525 GTP binding
GO:0003723 RNA binding

Cellular Component

GO:0005622 intracellular

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.