Family

Triabin/Procalin (IPR005657)

Short name: Triabi/Procalin

Overlapping homologous superfamilies

Family relationships

None.

Description

This family contains saliva proteins from haematophagous insects that counteract vertebrate host haemostasis events such as coagulation, vasoconstriction and platelet aggregation [PMID: 12421416]. These include:

  • Triabin, a serine-protease inhibitor with a calycin fold [PMID: 9342325]. It forms a non-covalent complex with thrombin at a molecular ratio of 1:1, and inhibits thrombin-induced platelet aggregation.
  • Procalin is the major allergen of Triatoma protracta saliva [PMID: 11509613].

Members of this family belong to MEROPS proteinase inhibitor family I59, clan IZ.

GO terms

Biological Process

GO:0030682 evasion or tolerance of host defense response

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam