MmgE/PrpD (IPR005656)

Short name: MmgE_PrpD

Overlapping homologous superfamilies

Family relationships


This entry represents proteins from the MmgE/PrpD family, which includes 2-methylcitrate dehydratase (PrpD; EC: PrpD is required for propionate catabolism, catalysing the third step of the 2-methylcitric acid cycle [PMID: 11782506]. This enzyme consists of two domains: a large domain with an all-helical fold and a smaller domain that folds into an alpha+beta domain [PMID: 16934291]. Cis-aconitic acid decarboxylase (CAD) shares high identity with proteins of the MmgE/PrpD family. CAD is essential for itaconic acid production in Aspergillus terreus [PMID: 18584171].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016829 lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.