Domain

Serine hydrolase FSH (IPR005645)

Short name: FSH_dom

Domain relationships

None.

Description

This domain can be found in budding yeast Fsh1/2/3, fission yeast Dfr1 and the human OVCA2 protein. Fsh1/2/3 are putative serine hydrolases [PMID: 14645503]. Dfr1 is a dihydrofolate reductase (DHFR) [PMID: 8088538]. OVCA2 is a putative serine-hydrolase that has been linked to cancers [PMID: 16368187]. Proteins containing this domain also includes Aspergillus terreus esterase LovG, which catalyzes the release of covalently bound dihydromonacolin L from LovB during lovastatin biosynthesis [PMID: 23653178].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam