Domain

TAP C-terminal (TAP-C) domain (IPR005637)

Short name: TAP_C_dom

Domain relationships

  • UBA-like (IPR009060)
    • TAP C-terminal (TAP-C) domain (IPR005637)

Description

The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling [PMID: 11875519]. The structure of the C-terminal domain is composed of four helices [PMID: 11875519]. The structure is related to the UBA domain.

The NXF family of mRNA nuclear export factors includes vertebrate NXF1 (also called tip-associated protein or mRNA export factor TAP), NXF2 (also called cancer/testis antigen CT39 or TAP-like protein TAPL-2), Caenorhabditis elegans NXF1 (ceNXF1), Saccharomyces cerevisiae mRNA nuclear export factor Mex67p and similar proteins. NXF proteins can stimulate nuclear export of mRNAs and facilitate the export of unspliced viral mRNA containing the constitutive transport element. An NXF protein is multi-domain with a nuclear localization sequence (NLS), a non-canonical mRNA-binding domain, and four leucine-rich repeats (LLR) at the N-terminal region. Its C-terminal part contains a NTF2-like domain and a ubiquitin-associated (UBA)-like domain, joined by flexible Pro-rich linker. Caenorhabditis elegans NXF1 are essential for the nuclear export of poly(A)+mRNA. In budding yeast, Mex67p binds mRNAs through its adaptor Yra1/REF. It also interacts directly with Nab2, an essential shuttling mRNA-binding protein required for export. Moreover, Mex67p associates with both nuclear pore protein (nucleoporin) FG repeats and Hpr1, a component of the TREX/THO complex linking transcription and export [PMID: 11875519, PMID: 20810649, PMID: 10567585, PMID: 11073998, PMID: 11583626, PMID: 12581645, PMID: 19401465, PMID: 11060011, PMID: 11256625, PMID: 10668806, PMID: 11259411, PMID: 9660949, PMID: 9175835, PMID: 10454577, PMID: 10323864, PMID: 10202158].

GO terms

Biological Process

GO:0051028 mRNA transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
SMART
Pfam
CDD