Terpene synthase, metal-binding domain (IPR005630)

Short name: Terpene_synthase_metal-bd

Overlapping homologous superfamilies

Domain relationships


Sequences containing this domain belong to the terpene synthase family. It has been suggested that this gene family be designated tps (for terpene synthase). Sequence comparisons reveal similarities between the monoterpene (C10) synthases, sesquiterpene (C15) synthases and the diterpene (C20) synthases. It has been split into six subgroups on the basis of phylogeny, called Tpsa-Tpsf [PMID: 9268308].

  • Tpsa includes vetispiradiene synthase Q39979, 5-epi- aristolochene synthase, Q40577 and (+)-delta-cadinene synthase P93665.
  • Tpsb includes (-)-limonene synthase, Q40322.
  • Tpsc includes copalyl diphosphate synthase (kaurene synthase A), O04408.
  • Tpsd includes taxadiene synthase, Q41594, pinene synthase, O24475 and myrcene synthase, O24474.
  • Tpse includes ent-kaurene synthase B Q39548.
  • Tpsf includes linalool synthase Q9ZPN5.

In the fungus Phaeosphaeria sp. (strain L487) the synthesis of ent-kaurene from geranylgeranyl dophosphate is promoted by a single bifunctional protein [PMID: 9268298].

This domain is involved in the cyclization of linear terpenes [PMID: 9295272, PMID: 12432096, PMID: 17261032, PMID: 20131801, PMID: 20624401].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016829 lyase activity
GO:0000287 magnesium ion binding
GO:0010333 terpene synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.