Negative modulator of initiation of replication SeqA (IPR005621)

Short name: SeqA

Overlapping homologous superfamilies

Family relationships



The binding of the negative modulator of initiation of replication (SeqA) protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation [PMID: 11457824]. SeqA tetramers are able to aggregate or multimerize in a reversible, concentration-dependent manner [PMID: 11457824]. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor [PMID: 11442835].

GO terms

Biological Process

GO:0032297 negative regulation of DNA-dependent DNA replication initiation

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.