BSD domain (IPR005607)
Short name: BSD_dom
Overlapping homologous superfamilies
- BSD domain superfamily (IPR035925)
The BSD domain is an about 60-residue long domain named after the BTF2-like transcription factors, Synapse-associated proteins and DOS2-like proteins in which it is found. Additionally, it is also found in several hypothetical proteins. The BSD domain occurs in one or two copies in a variety of species ranging from primal protozoan to human. It can be found associated with other domains such as the BTB domain (see PDOC50097) or the U-box in multidomain proteins. The function of the BSD domain is unknown [PMID: 11943536].
Secondary structure prediction indicates the presence of three predicted alpha helices, which probably form a three-helical bundle in small domains. The third predicted helix contains neighbouring phenylalanine and tryptophan residues - less common amino acids that are invariant in all the BSD domains identified and that are the most striking sequence features of the domain [PMID: 11943536].Some proteins known to contain one or two BSD domains are listed below:
- Mammalian TFIIH basal transcription factor complex p62 subunit (GTF2H1).
- Yeast RNA polymerase II transcription factor B 73 kDa subunit (TFB1), the homologue of BTF2.
- Yeast DOS2 protein. It is involved in single-copy DNA replication and ubiquitination.
- Drosophila synapse-associated protein SAP47.
- Mammalian SYAP1.
- Various Arabidopsis thaliana (Mouse-ear cress) hypothetical proteins.