ELK domain (IPR005539)

Short name: ELK_dom

Overlapping homologous superfamilies


Domain relationships



Homeobox genes, which encode homeodomain (HD) transcription factors, are known to be key regulators of both plant and animal development. In plants homeobox genes are divided into several groups by sequences, one of which is the KNOX (for knotted1-type homeobox) family. Proteins of this family share other conserved domains, the KNOX domain and ELK domain, which is immediately upstream of the HD. The ELK domain spans ~21 amino acids and was dubbed for a highly conserved series of Glu, Leu, and Lys amino acids. It could function as a nuclear localization signal. The ELK domain also is considered to act as a protein-protein interaction domain, but the precise role of this domain has not been determined [PMID: 7866030, PMID: 10449577, PMID: 11549765, PMID: 12034492].

The ELK domain contains repeating hydrophobic residues and has been predicted to form an amphipathic helix [PMID: 7866030].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles