Integral membrane protein TerC (IPR005496)

Short name: Integral_membrane_TerC

Overlapping homologous superfamilies


Family relationships


A family containing a number of integral membrane proteins is named after TerC protein. TerC has been implicated in resistance to tellurium, and may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of a group of clinical isolates for antibiotic and heavy metal ion resistance [PMID: 10069007]. The determinant of the strain's tellurite resistance was located on a large conjugative plasmid, and analyses showed the genes terB, terC, terD and terE were essential for conservation of this resistance. Members of this family contain a number of conserved aspartates which may be involved in metal ion binding.

A TerC homologue is known from the chloroplast thylakoid membrane from Arabidopsis which is important for thylakoid membrane biogenesis in the developing chloroplast [PMID: 18429937]; it is required for insertion of proteins into the thylakoid membrane [PMID: 24612058].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.